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10.1016/j.addr.2012.09.037 2 AnandP.KunnumakkaraA

Matthew S, Genelle L, Kevan J

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(2) The new medical service or technology is the subject of a complete and active FDA marketing authorization request and documentation of FDA acceptance or filing of the request is provided to CMS

Future studies should incorporate mechanism-relevant biological markers, including serum BDNF to index neurotrophic signaling, inflammatory markers such as CRP and IL-6, measures of HPA-axis activity such as the cortisol awakening response, and neuroimaging markers (e.g., fMRI-based assessments of hippocampal connectivity), to more precisely characterize treatment response and patient stratification